Yohimbine has significant side effects, such as anxiety reactions. According to the Mayo Clinic, yohimbine can be dangerous if used in excessive amounts.
[19]
Higher doses of oral yohimbine may create numerous side effects, such as
rapid heart rate,
high blood pressure, overstimulation,
insomnia and/or sleeplessness. Some effects in rare cases were
panic attacks,
hallucinations,
headaches,
dizziness, and
skin flushing.
[20]
More serious adverse effects may include
seizures and
renal failure. Yohimbine should not be consumed by anyone with
liver,
kidney,
heart disease, or a
psychological disorder.
[20]
The
therapeutic index of yohimbine is quite low; the range between an effective dose and a dangerous dose is very narrow.
[20] This may also lead to precipitation of panic disorder type reactions.
Yohimbine in combination with
modafinil causes dangerous acute rapid heart beat and acute increased blood pressure.